el-Sabbagh H M, Meshali M, Ghanem A, Abdel-Aleem H
Pharmazie. 1984 Jun;39(6):404-6.
The effect of the diluents, lactose and calcium carbonate and of the binders, syrup, gelatin, methylcellulose and Eudragit E on the physical properties of phenazopyridine hydrochloride (PNHCl) granules was evaluated. A correlation existed between the granules' physical properties and those of their compressed tablets. With regard to drug release, lactose-syrup 30% was the best of all diluent-binder combinations, followed by lactose-methylcellulose 4%. Also lactose was found to be superior to calcium carbonate in drug release when gelatin and methylcellulose were used as binders. Eudragit E was the best binder with calcium carbonate in this respect. On the other hand, the bioavailability of PNHCl in humans was the same when lactose was used with either gelatin, syrup or methylcellulose, but higher than that obtained with a combination of calcium carbonate and Eudragit E 15%.
评估了稀释剂乳糖和碳酸钙以及黏合剂糖浆、明胶、甲基纤维素和聚丙烯酸树脂E对盐酸非那吡啶（PNHCl）颗粒物理性质的影响。颗粒的物理性质与其压制片的物理性质之间存在相关性。在药物释放方面，30%乳糖-糖浆是所有稀释剂-黏合剂组合中最佳的，其次是4%乳糖-甲基纤维素。当使用明胶和甲基纤维素作为黏合剂时，还发现乳糖在药物释放方面优于碳酸钙。在这方面，聚丙烯酸树脂E是与碳酸钙搭配的最佳黏合剂。另一方面，当乳糖与明胶、糖浆或甲基纤维素一起使用时，PNHCl在人体中的生物利用度相同，但高于碳酸钙与15%聚丙烯酸树脂E组合时的生物利用度。
