Pak R C, Tsim K W, Cheng C H
Pharmacology. 1984;29(3):121-7. doi: 10.1159/000138002.
The responsiveness of the hepatic microsomal aryl hydrocarbon hydroxylase (AHH) to testosterone enanthate (TE; 2.5 mumol/kg/day for 9 days) was sex-dependent in adult rats, the enzyme being very resistant to TE in normal adult or ovariectomized females. Administration of testosterone propionate or diethylstilbestrol (1.45 mumol) to neonatal female rats at 1 and 3 days of age did not increase the responsivity to TE in adulthood. However, exposure of female rats to TE (5.0 mumol/kg/day) during the peripubertal period (35-50 days old) resulted in increased sensitivity to TE (+55.2%) when tested in adulthood. The responsivity was further potentiated (+109.3%) if the animals were ovariectomized at 28 days of age. Prepubescent ovariectomized females which received corn oil or estradiol benzoate (1.5 mumol/kg on alternate days) during puberty were not able to respond to TE significantly. These results suggest that the refractoriness of the hepatic AHH to testosterone in adult female rats is determined by the absence of testosterone, as well as the presence of estrogens, during puberty.
成年大鼠肝脏微粒体芳烃羟化酶（AHH）对庚酸睾酮（TE；2.5 μmol/kg/天，持续9天）的反应具有性别依赖性，在正常成年雌性或去卵巢雌性大鼠中，该酶对TE具有很强的抗性。在新生雌性大鼠1日龄和3日龄时给予丙酸睾酮或己烯雌酚（1.45 μmol），并不会增加成年后对TE的反应性。然而，雌性大鼠在青春期（35 - 50日龄）期间暴露于TE（5.0 μmol/kg/天），成年后对TE的敏感性增加（+55.2%）。如果动物在28日龄时进行去卵巢手术，反应性会进一步增强（+109.3%）。青春期前接受玉米油或苯甲酸雌二醇（1.5 μmol/kg，隔天给药）的去卵巢雌性大鼠对TE无明显反应。这些结果表明，成年雌性大鼠肝脏AHH对睾酮的不应性是由青春期期间睾酮缺乏以及雌激素的存在所决定的。
