Cheng C H, Tsim K W, Wai M K, Pak R C
Int J Pept Protein Res. 1984 May;23(5):521-7. doi: 10.1111/j.1399-3011.1984.tb02753.x.
Administration of testosterone enanthate to adult female rats lowered the level of hepatic prolactin receptor. Pubertal exposure of intact female rats to testosterone enanthate at the dose used did not affect the level of hepatic prolactin receptor in adults. However, the responsivity of such treated rats to testosterone challenge in adulthood was enhanced. Prepubertal ovariectomy of female rats lowered the level of hepatic prolactin receptor in adulthood. Exposure of the ovariectomized rats during puberty to mestranol (ethynylestradiol 3-methyl ether) at the dose used did not restore the normal adult female rat's level of hepatic prolactin receptor. However, they did become more resistant to subsequent testosterone challenge in adulthood. Exposure of prepubescent ovariectomized rats to testosterone enanthate during puberty reduced the already diminished level of hepatic prolactin receptor further. In addition, these rats were rendered more responsive to testosterone challenge in adulthood.
给成年雌性大鼠注射庚酸睾酮会降低肝脏催乳素受体水平。完整雌性大鼠在青春期以所用剂量接触庚酸睾酮，对成年大鼠肝脏催乳素受体水平无影响。然而，此类处理过的大鼠成年后对睾酮激发的反应性增强。雌性大鼠青春期前卵巢切除会降低成年后肝脏催乳素受体水平。青春期将卵巢切除的大鼠以所用剂量接触炔雌醇甲醚（炔雌醇3 - 甲醚），并未恢复成年正常雌性大鼠肝脏催乳素受体水平。然而，它们成年后对随后的睾酮激发确实变得更具抗性。青春期前卵巢切除的大鼠在青春期接触庚酸睾酮会使本已降低的肝脏催乳素受体水平进一步降低。此外，这些大鼠成年后对睾酮激发的反应性变得更强。
