牛磺酸对兔慢性主动脉瓣关闭不全所致充血性心力衰竭的有益作用。

Beneficial effect of taurine on congestive heart failure induced by chronic aortic regurgitation in rabbits.

作者信息

Azuma J, Takihara K, Awata N, Ohta H, Sawamura A, Harada H, Kishimoto S

出版信息

Res Commun Chem Pathol Pharmacol. 1984 Aug;45(2):261-70.

Abstract

Taurine (2-aminoethanesulfonic acid) is known to have a cardiotonic action. The present study was designed to see whether oral treatment with taurine could improve the status of congestive heart failure induced by aortic regurgitation. Nine rabbits were treated daily with taurine (100 mg/kg) after producing aortic regurgitation. Cumulative mortality at 8 weeks in the non-treated group was 52% compared with 11% in the taurine-treated group (p less than 0.05). Cardiac function (max dP/dt) was significantly decreased in rabbits with aortic regurgitation, whereas in taurine-treated rabbits, cardiac function was maintained the same as control. The present data suggest that taurine prevented the rapid progress of heart failure, and consequently prolonged the life expectancy.

摘要

牛磺酸（2-氨基乙磺酸）已知具有强心作用。本研究旨在观察口服牛磺酸是否能改善由主动脉瓣反流引起的充血性心力衰竭状况。在造成主动脉瓣反流后，对9只兔子每日给予牛磺酸（100毫克/千克）治疗。未治疗组8周时的累积死亡率为52%，而牛磺酸治疗组为11%（p<0.05）。主动脉瓣反流兔子的心脏功能（最大dP/dt）显著降低，而在牛磺酸治疗的兔子中，心脏功能维持在与对照组相同的水平。目前的数据表明，牛磺酸可防止心力衰竭的快速进展，从而延长预期寿命。