Bürgin M, Schmidt M, Reutter F
Schweiz Med Wochenschr. 1984 Aug 18;114(33):1118-23.
The presence and extent of focal-segmental glomerulosclerosis/hyalinosis (FSSH) was determined in 79 autopsy cases of analgesic nephropathy and correlated with the levels of proteinuria, serum creatinine and arterial blood pressure. FSSH was present in 77% of cases. The extent of FSSH correlates positively with increasing proteinuria and serum creatinine. The widely scattered pattern suggests a multifactorial pathogenesis for FSSH in analgesic nephropathy, including, for example, glomerular overload and arterial hypertension. Mesangial proliferative glomerulonephritis was observed in only two cases.
在79例止痛剂肾病尸检病例中确定了局灶节段性肾小球硬化/玻璃样变（FSSH）的存在及程度，并将其与蛋白尿水平、血清肌酐和动脉血压进行关联分析。77%的病例存在FSSH。FSSH的程度与蛋白尿和血清肌酐升高呈正相关。广泛散在的模式提示止痛剂肾病中FSSH的发病机制是多因素的，例如包括肾小球负荷过重和动脉高血压。仅在两例病例中观察到系膜增生性肾小球肾炎。
