Reintgen D S, Paull D E, Seigler H F, Cox E B, McCarty K S
Surg Gynecol Obstet. 1984 Oct;159(4):367-72.
While data concerning melanoma survival differences between the sexes as they relate to anatomic site, stage and age is scattered throughout the literature, few single studies on one large population of patients with melanoma have specifically addressed all the confounding variables proposed to account for such sex related survival differences. Data were collected for 1,489 patients with melanoma observed at Duke University Comprehensive Cancer Center. Females had a more favorable prognosis than males. This survival difference could not be fully explained by differences in the anatomic site of the primary, Clark level of invasion, histologic type or ulceration of the primary lesion or age at diagnosis between males and females. There is growing epidemiologic and biochemical evidence that melanoma may be affected by sex hormones.
虽然有关黑色素瘤患者性别生存差异与解剖部位、分期和年龄关系的数据分散在各类文献中，但针对一大群黑色素瘤患者的单一研究中，很少有专门探讨所有可能导致此类性别相关生存差异的混杂变量的。我们收集了在杜克大学综合癌症中心观察到的1489例黑色素瘤患者的数据。女性的预后比男性更有利。这种生存差异不能完全用原发灶的解剖部位、克拉克侵袭分级、组织学类型或原发灶溃疡情况以及男女诊断时年龄的差异来解释。越来越多的流行病学和生化证据表明，黑色素瘤可能受性激素影响。
