Kuhlmann R S, Kolesari G L
Teratology. 1984 Aug;30(1):55-9. doi: 10.1002/tera.1420300108.
Spontaneous aortic arch and cardiac malformations occur in White Leghorn chick embryos at a relatively high rate. Although this breed of Gallus domesticus is widely used for biomedical and biological research, no previous study has recorded the incidence of these defects. We found aortic arch malformations in 7.1% (14 of 196) and ventricular septal defects in 11.7% (23 of 196) of living embryos. Defects occurred alone or as a combined pattern. Our findings suggest that the cardiovascular defects in the chick embryo documented in past studies may, in some cases, have been part of normal spontaneous occurrence, rather than the major result of experimental manipulation.
自发性主动脉弓和心脏畸形在白来航鸡胚胎中出现的频率相对较高。尽管这种家鸡品种被广泛用于生物医学和生物学研究，但此前尚无研究记录这些缺陷的发生率。我们发现，在存活胚胎中，主动脉弓畸形的发生率为7.1%（196例中有14例），室间隔缺损的发生率为11.7%（196例中有23例）。缺陷可单独出现或呈联合模式。我们的研究结果表明，过去研究中记录的鸡胚胎心血管缺陷在某些情况下可能是正常自发发生的一部分，而非实验操作的主要结果。
