膀胱癌及其他泌尿生殖道恶性肿瘤患者体内的循环免疫复合物。

Circulating immune complexes in patients with bladder cancer and other malignancies of the urogenital tract.

作者信息

Kobayashi K, Umeda T, Akaza H, Niijima T, Aikawa T, Tanimoto K

出版信息

Urol Int. 1984;39(4):232-5. doi: 10.1159/000280982.

Abstract

Sera from 70 patients with bladder cancer, 26 patients with kidney cancer, and 20 patients with prostate cancer were studied for the presence of circulating immune complexes (CIC) utilizing the human red blood cell (HRBC) radioimmunoassay. Elevated CIC levels were found in 32% of patients with bladder cancer, 30% of patients with kidney cancer, and 20% of patients with prostate cancer. For comparison, CIC was also measured in 37 sera from patients with bladder cancer by the polyethylene glycol precipitation complement consumption (PEG-CC) test. 13 of them (35%) had elevated CIC levels. The correlation between the results of the two tests was significant. There were significant correlations between CIC levels and the extent of tumor invasion and the degree of malignancy in patients with bladder cancer. The elevation of CIC level was also significantly associated with poor prognosis of these bladder cancer patients. It is proposed that measurement of CIC in patients with bladder cancer by the HRBC radioimmunoassay may be useful to evaluate their stage, degree of malignancy, and prognosis.

摘要

利用人红细胞（HRBC）放射免疫分析法，对70例膀胱癌患者、26例肾癌患者和20例前列腺癌患者的血清进行循环免疫复合物（CIC）检测。结果发现，32%的膀胱癌患者、30%的肾癌患者和20%的前列腺癌患者CIC水平升高。作为对照，还采用聚乙二醇沉淀补体消耗（PEG-CC）试验对37例膀胱癌患者的血清进行CIC检测，其中13例（35%）CIC水平升高。两种检测结果之间的相关性显著。膀胱癌患者的CIC水平与肿瘤浸润程度和恶性程度之间存在显著相关性。CIC水平升高也与这些膀胱癌患者的预后不良显著相关。建议采用HRBC放射免疫分析法检测膀胱癌患者的CIC，这可能有助于评估其分期、恶性程度和预后。