Johnson D E, Lo R K
Urology. 1984 Oct;24(4):308-11. doi: 10.1016/0090-4295(84)90197-3.
Twenty-two patients with squamous carcinoma of the penis underwent groin dissections for histologically proved inguinal lymph node metastases, either around the time that the primary tumor was treated (early therapeutic dissection, 14 patients) or later, after they had been clinically judged free of regional nodal metastases at diagnosis (late therapeutic dissections, 8 patients). Three- and five-year survival rates for the patients who underwent early therapeutic dissections were 71 per cent and 57 per cent, respectively, as opposed to 50 per cent and 13 per cent, respectively, for patients who underwent late therapeutic dissections. These findings suggest that a "wait and watch" policy in patients with clinically negative nodes at diagnosis is no longer justified.
22例阴茎鳞状细胞癌患者因组织学证实有腹股沟淋巴结转移而接受了腹股沟淋巴结清扫术，其中14例在治疗原发肿瘤前后进行了早期治疗性清扫，另外8例在诊断时临床判断无区域淋巴结转移，之后进行了晚期治疗性清扫。接受早期治疗性清扫的患者3年和5年生存率分别为71%和57%，而接受晚期治疗性清扫的患者3年和5年生存率分别为50%和13%。这些结果表明，对于诊断时临床淋巴结阴性的患者，“观察等待”策略不再合理。
