Moĭseenok A G, Nefedov L I, Sheĭbak V M, Omel'ianchik S N
Vopr Pitan. 1984 Jul-Aug(4):37-9.
The feeding of white rats with a synthetic diet deprived of pantothenic acid (PAA) for 10 weeks led to a decrease in the content of acid-soluble CoA (AS-CoA) and to an increase in the liver taurine and glycine concentration. One hour after pantothenate injection (30 mg/kg) to PAA-deficient animals the level of AS-CoA rose by 96%, whereas after administration of an equimolar dose of cystein by 63%. Combined administration of CoA precursors did not result in summation of the effects. In all the cases of cystein injections, substantial changes were recorded in the structure of the liver amino acid pool, which were less marked if cystein was combined with pantothenate. It is assumed that the metabolism of cystein, glycine and, probably, that of alanine may depend on the changes in the CoA pool in hepatocytes.
用缺乏泛酸（PAA）的合成饲料喂养白鼠10周，导致酸溶性辅酶A（AS-CoA）含量降低，肝脏中牛磺酸和甘氨酸浓度升高。向缺乏PAA的动物注射泛酸盐（30mg/kg）1小时后，AS-CoA水平上升了96%，而给予等摩尔剂量的半胱氨酸后上升了63%。联合给予辅酶A前体并未导致效果叠加。在所有注射半胱氨酸的情况下，肝脏氨基酸库的结构都发生了显著变化，若半胱氨酸与泛酸盐联合使用，这种变化则不太明显。据推测，半胱氨酸、甘氨酸以及可能还有丙氨酸的代谢可能取决于肝细胞中辅酶A库的变化。
