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[泛酸缺乏以及给予维生素或其衍生物时肾上腺皮质的功能活动]

[Adrenal cortex functional activity in pantothenate deficiency and the administration of the vitamin or its derivatives].

作者信息

Tarasov Iu A, Sheĭbak V M, Moĭseenok A G

出版信息

Vopr Pitan. 1985 Jul-Aug(4):51-4.

PMID:4060684
Abstract

Study of the corticosteroid content in the adrenals and blood of rats under pantothenate deficiency has demonstrated a decrease in adrenocortical function. A single administration of pantothenate in a dose of 3.3 mg/kg reduced the influence of hypovitaminosis on the adrenals. The pantothenate derivatives (pantethine, 4'-phosphopantothenate and CoA in particular) injected to intact animals in a single dose equimolar to 3.3 mg/kg calcium pantothenate per kg bw had a marked steroidogenous effect.

摘要

对泛酸缺乏的大鼠肾上腺和血液中皮质类固醇含量的研究表明,肾上腺皮质功能有所下降。单次给予3.3毫克/千克剂量的泛酸可减轻维生素缺乏对肾上腺的影响。以每千克体重与3.3毫克/千克泛酸钙等摩尔的单剂量,将泛酸衍生物(特别是泛硫乙胺、4'-磷酸泛酸和辅酶A)注射到正常动物体内,具有显著的类固醇生成作用。

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1
[Adrenal cortex functional activity in pantothenate deficiency and the administration of the vitamin or its derivatives].[泛酸缺乏以及给予维生素或其衍生物时肾上腺皮质的功能活动]
Vopr Pitan. 1985 Jul-Aug(4):51-4.
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[A change in the CoA concentration in the organs of young rats following injection with pantothenate derivatives].[注射泛酸盐衍生物后幼鼠器官中辅酶A浓度的变化]
Vopr Med Khim. 1974 Jul-Aug;20(4):363-7.
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Hepatic CoA, S-acyl-CoA, biosynthetic precursors of the coenzyme and pantothenate-protein complexes in dietary pantothenic acid deficiency.膳食泛酸缺乏时肝脏辅酶A、S-酰基辅酶A、辅酶生物合成前体及泛酸-蛋白质复合物的情况。
Int J Vitam Nutr Res. 1987;57(1):71-7.
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[Distribution and biotransformation of labelled pantothenate in cytoplasmic and mitochondrial fractions of the rat liver with a deficiency of pantothenic acid].[泛酸缺乏大鼠肝脏细胞质和线粒体组分中标记泛酸盐的分布与生物转化]
Vopr Pitan. 1989 Sep-Oct(5):50-3.
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Pantethine and pantothenate effect on the CoA content of rat liver.泛硫乙胺和泛酸盐对大鼠肝脏辅酶A含量的影响。
Int J Vitam Nutr Res. 1984;54(2-3):211-6.
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[Changes in the content of the thiol form of the acetylation coenzyme in the liver during administration of vitamin B3-active compounds to intact and locally irradiated animals].[在给未受照射和局部受照射动物施用维生素B3活性化合物期间肝脏中乙酰化辅酶硫醇形式含量的变化]
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[Quantitative evaluation of the ultrastructural restructurings of the adrenal cortex of rats under stress after preliminary administration of corticotropin].
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Correction of a genetic deficiency in pantothenate kinase 1 using phosphopantothenate replacement therapy.使用磷酸泛酸替代疗法纠正泛酸激酶1的基因缺陷。
Mol Genet Metab. 2015 Dec;116(4):281-8. doi: 10.1016/j.ymgme.2015.10.011. Epub 2015 Oct 29.
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[Acid-soluble CoA and free amino acid levels in the liver of pantothenic acid-deficient albino rats after separate and combined administration of panthotenic acid and cysteine].[泛酸缺乏的白化病大鼠肝脏中酸溶性辅酶A和游离氨基酸水平在分别及联合给予泛酸和半胱氨酸后]
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