Müller G
Z Gesamte Inn Med. 1984 Jul 15;39(14):321-5.
Pancreatic lipase (triacylglycerol-acylhydrolase EC 3.1.1.3) hydrolyzes triglycerides on the lipid-water-boundary surfaces of micelles. The adsorption of the pancreatic lipase to the triglyceride boundary surfaces is inhibited by bile acid salts. Whereas colipase can be bound to boundary surfaces covered by bile acids and to pancreatic lipase. Colipase eliminates the inhibitory effect of physiologic concentrations of bile acid salts on the activity of lipase. The lipolysis by pancreatic lipase is characterized by activation of products and a biphasic kinetics. Extrapancreatic lipases of tongue, pharynx, oesophagus and stomach evoke the lipolysis of the fats contained in food.
胰脂肪酶（甘油三酯酰基水解酶，EC 3.1.1.3）在微团的脂质 - 水界面上水解甘油三酯。胆汁酸盐会抑制胰脂肪酶对甘油三酯界面的吸附。而辅脂酶可以结合到被胆汁酸覆盖的界面以及胰脂肪酶上。辅脂酶可消除生理浓度的胆汁酸盐对脂肪酶活性的抑制作用。胰脂肪酶的脂解作用具有产物激活和双相动力学的特征。舌、咽、食管和胃的胰腺外脂肪酶可引起食物中所含脂肪的脂解作用。
