Inturrisi C E
Am J Med. 1984 Sep 10;77(3A):27-37. doi: 10.1016/s0002-9343(84)80100-x.
The clinical pharmacology of the narcotic-type analgesics is discussed in depth. Relative analgesic potency, peak and duration of analgesia, oral potency, and adverse effects are reviewed, With an emphasis on the clinical application of this knowledge. The differences among psychologic dependence, physical dependence, and tolerance are carefully delineated. Guidelines are provided for using narcotic-type analgesics in the management of patients with cancer.
深入讨论了麻醉型镇痛药的临床药理学。回顾了相对镇痛效力、镇痛的峰值和持续时间、口服效力以及不良反应，并重点强调了这些知识的临床应用。仔细阐述了心理依赖、身体依赖和耐受性之间的差异。提供了在癌症患者管理中使用麻醉型镇痛药的指南。
