Horwitz R I, Lamas A M, Peck D
Am J Med. 1984 Oct;77(4):621-4. doi: 10.1016/0002-9343(84)90351-6.
A case-control study was conducted to assess whether certain "high-risk" mammographic parenchymal patterns are associated with the increased occurrence of breast cancer in postmenopausal women. Patients in the case group included 105 women with histologically confirmed breast cancer; subjects in the control group included 104 women with fibrocystic breast disease and 103 women with clinically normal breasts. All mammographic results were evaluated "blindly" by a radiologist who classified the breast parenchyma into "high-risk" and "low-risk" categories according to the criteria proposed by Wolfe. These data showed a similar proportion of allegedly "high-risk" breast parenchymal patterns among patients in all three groups. The finding that breast parenchymal patterns are not associated with an increased risk of breast cancer in women 50 years of age or older is consistent with the results of earlier studies in which the association is present only in younger, premenopausal women, and is absent in older, predominantly postmenopausal women. Consequently, it is concluded that these parenchymal patterns should not be used to select postmenopausal women for breast cancer screening programs, or to guide the evaluation of postmenopausal women with breast lumps or symptoms.
开展了一项病例对照研究，以评估某些“高危”乳腺钼靶实质模式是否与绝经后女性患乳腺癌的几率增加有关。病例组的患者包括105名经组织学确诊为乳腺癌的女性；对照组的受试者包括104名患有纤维囊性乳腺病的女性和103名乳房临床检查正常的女性。一位放射科医生对所有乳腺钼靶检查结果进行了“盲法”评估，该医生根据沃尔夫提出的标准将乳腺实质分为“高危”和“低危”两类。这些数据显示，所有三组患者中所谓“高危”乳腺实质模式的比例相似。乳腺实质模式与50岁及以上女性患乳腺癌风险增加无关这一发现，与早期研究结果一致，早期研究表明这种关联仅存在于较年轻的绝经前女性中，而在年龄较大、主要为绝经后的女性中不存在。因此，得出结论，这些实质模式不应被用于选择绝经后女性进行乳腺癌筛查项目，或指导对有乳房肿块或症状的绝经后女性的评估。
