Arthur J E, Ellis I O, Flowers C, Roebuck E, Elston C W, Blamey R W
Department of Histopathology, City Hospital, Nottingham.
Br J Radiol. 1990 Nov;63(755):845-9. doi: 10.1259/0007-1285-63-755-845.
In the UK Trial for the Early Detection of Breast Cancer in Nottingham, 119 women were identified as having fibrocystic change with epithelial hyperplasia or in situ carcinoma. Their mammograms were classified according to Wolfe's criteria and the corresponding histology for each patient was classified for degrees of epithelial hyperplasia, atypia and in situ neoplasia using Page's criteria. A control population of patients presenting for breast screening was used to represent the general population. No correlation was found between the four mammographic Wolfe patterns, N1, P1, P2 and DY and histological evidence of epithelial hyperplasia, atypia or in situ carcinoma. A further study was carried out to determine histological features of Wolfe pattern, using radiological examination of resected breast tissue. The variation in Wolfe pattern was related to the distribution of fibrous and adipose tissue in the breast interlobular stroma and appeared to have no relationship to epithelial parenchymal content. This information does not support the hypothesis that radiographic densities of P2 and DY patterns correspond to high risk epithelial proliferation.
在英国诺丁汉进行的乳腺癌早期检测试验中，119名女性被确定患有伴有上皮增生或原位癌的纤维囊性改变。她们的乳房X光片根据沃尔夫标准进行分类，并且使用佩奇标准将每位患者相应的组织学分类为上皮增生、异型性和原位肿瘤形成的程度。一组前来进行乳房筛查的对照人群被用来代表普通人群。在四种乳房X光沃尔夫模式（N1、P1、P2和DY）与上皮增生、异型性或原位癌的组织学证据之间未发现相关性。开展了一项进一步的研究，通过对切除的乳腺组织进行放射学检查来确定沃尔夫模式的组织学特征。沃尔夫模式的变化与乳腺小叶间质中纤维和脂肪组织的分布有关，并且似乎与上皮实质含量无关。该信息不支持P2和DY模式的放射学密度对应于高风险上皮增殖这一假设。
