Alger L S, Kisner H J, Nagey D A
Am J Obstet Gynecol. 1984 Oct 15;150(4):380-5. doi: 10.1016/s0002-9378(84)80143-x.
Previous studies of the significance of meconium-stained second-trimester amniotic fluid have relied upon visual assessment of fluid color as the screening procedure followed by spectrophotometric analysis at 405 nm to confirm the presence of "meconium" (incidence of 1% to 3%). This assumes that in the absence of discolored fluid there is no "meconium." In the present study, prospective spectrophotometric analysis was performed on 123 serially obtained amniotic fluid specimens sampled at 15 to 19 weeks' gestation. The presence of an absorbing species peaking near 405 nm was observed in 91% of the samples. This substance is generally not present at term. Its presence does not correlate with pregnancy outcome and is of no prognostic significance. However, it is related to gestational age and placental implantation site. Further analysis supports the hypothesis that our tracings represent a variety of pigments derived from the metabolism of intra-amniotic hemoglobin resulting from the normal physiologic development of early pregnancy.
先前关于孕中期羊水胎粪污染意义的研究，依赖于对羊水颜色的视觉评估作为筛查程序，随后在405nm处进行分光光度分析以确认“胎粪”的存在（发生率为1%至3%）。这假定在羊水未变色的情况下不存在“胎粪”。在本研究中，对123例在妊娠15至19周时连续获取的羊水样本进行了前瞻性分光光度分析。在91%的样本中观察到在405nm附近有吸收峰的吸收物质。这种物质在足月时通常不存在。其存在与妊娠结局无关，也没有预后意义。然而，它与孕周和胎盘着床部位有关。进一步分析支持这样的假设，即我们的检测结果代表了多种由孕早期正常生理发育过程中羊膜内血红蛋白代谢产生的色素。
