Ross M G, Ervin G, Leake R D, Fu P, Fisher D A
Am J Obstet Gynecol. 1984 Oct 15;150(4):421-5. doi: 10.1016/s0002-9378(84)80151-9.
The fetal lung, filled with fluid during intrauterine life, is recognized as a site of fluid production, significantly contributing to amniotic fluid volume. To assess possible hormonal control of lung liquid production, we studied the effect of intravenous vasopressin or vasotocin on lung liquid production in chronically catheterized fetal sheep. Both vasopressin and vasotocin infusion resulted in a significant decrease in lung fluid production (38% and 40%, respectively) when compared to that in control animals receiving saline infusion. There was no significant change in lung fluid osmolality, sodium, or potassium. These findings suggest that lung liquid production in utero may be regulated by the fetus and that vasopressin or vasotocin may be of physiologic importance in lung fluid dynamics during the third trimester of ovine pregnancy and perhaps during parturition.
胎儿的肺在子宫内生活期间充满液体，被认为是液体产生的部位，对羊水的量有显著贡献。为了评估肺液产生可能的激素控制，我们研究了静脉注射血管加压素或催产素对长期插管的胎儿绵羊肺液产生的影响。与接受生理盐水输注的对照动物相比，血管加压素和催产素输注均导致肺液产生显著减少（分别为38%和40%）。肺液渗透压、钠或钾没有显著变化。这些发现表明，子宫内的肺液产生可能受胎儿调节，血管加压素或催产素可能在绵羊妊娠晚期以及可能在分娩期间的肺液动力学中具有生理重要性。
