Davis T A, Gause G, Perks A M, Cassin S
Department of Physiology, College of Medicine, University of Florida, Gainesville 32610.
Am J Physiol. 1992 Jun;262(6 Pt 2):R1117-20. doi: 10.1152/ajpregu.1992.262.6.R1117.
These studies were designed to investigate the relationship between body fluid volume expansion and secretion of lung liquid in fetal sheep. Twelve fetal animals were used for saline infusion studies after providing them with indwelling vascular catheters and an exteriorized tracheal loop. An additional 10 animals were used as controls. Lung liquid production was measured using an impermeant tracer technique (Blue Dye Dextran). Saline infusion at 1.6, 4.0, 15.6, and 19.2 ml.kg-1.h-1 did not alter significantly lung liquid secretion rates. These results demonstrate that 1) intravenous infusion of saline at relatively high rates in the ovine fetus does not affect net fetal lung liquid formation rate, and 2) the lungs of chronically catheterized, unanesthetized fetal sheep probably do not participate in regulation of excess fluid and electrolytes.
这些研究旨在调查胎羊体液量扩张与肺液分泌之间的关系。在给12只胎羊植入血管内导管并外置气管环后，用于盐水输注研究。另外10只动物用作对照。使用非渗透性示踪技术（蓝色葡聚糖）测量肺液生成。以1.6、4.0、15.6和19.2 ml.kg-1.h-1的速率输注盐水，并未显著改变肺液分泌速率。这些结果表明：1）在绵羊胎儿中以相对较高的速率静脉输注盐水不会影响胎儿肺液的净生成率；2）长期插管、未麻醉的胎羊的肺可能不参与过量液体和电解质的调节。
