Taylor M R, Guerry D, Bondi E E, Shields J A, Augsburger J J, Lusk E J, Elder D E, Clark W H, Van Horn M
Am J Ophthalmol. 1984 Oct 15;98(4):478-82. doi: 10.1016/0002-9394(84)90135-1.
The occurrence of uveal and cutaneous malignant melanoma and the dysplastic nevus syndrome in the same individual suggests an etiologic relationship among these diseases. Thus, the dysplastic nevus syndrome could be viewed as marking an increased risk of both cutaneous and ocular melanoma. We postulated that if such a relationship exists, patients with both forms of melanoma should have a high prevalence of dysplastic nevi. We examined 44 patients (31 women and 13 men ranging in age from 20 to 80 years) with uveal melanoma for evidence of cutaneous melanoma and dysplastic nevi. We also examined photographs of 46 patients (24 men and 22 women ranging in age from 19 to 67 years) with nonfamilial cutaneous melanoma to determine the prevalence of dysplastic nevi. We found a 4.5% prevalence of dysplastic nevi in patients with uveal melanoma, significantly lower than the 41% prevalence in patients with cutaneous melanoma (two of 44 patients vs 19 of 46 patients). This study indicates that uveal and cutaneous melanoma are not etiologically linked through dysplastic nevi and suggests that patients with uveal melanoma are no more likely to have cutaneous dysplastic nevi than the general population.
同一个体中出现葡萄膜和皮肤恶性黑色素瘤以及发育异常痣综合征提示这些疾病之间存在病因学关联。因此，发育异常痣综合征可被视为皮肤和眼部黑色素瘤风险增加的标志。我们推测，如果存在这样的关联，两种形式黑色素瘤的患者发育异常痣的患病率应该较高。我们检查了44例（31名女性和13名男性，年龄在20至80岁之间）葡萄膜黑色素瘤患者，以寻找皮肤黑色素瘤和发育异常痣的证据。我们还检查了46例（24名男性和22名女性，年龄在19至67岁之间）非家族性皮肤黑色素瘤患者的照片，以确定发育异常痣的患病率。我们发现葡萄膜黑色素瘤患者中发育异常痣的患病率为4.5%，显著低于皮肤黑色素瘤患者中41%的患病率（44例患者中的2例 vs 46例患者中的19例）。这项研究表明，葡萄膜和皮肤黑色素瘤在病因学上并非通过发育异常痣相联系，并且提示葡萄膜黑色素瘤患者出现皮肤发育异常痣的可能性并不比普通人群更高。
