Hammer H, Oláh J, Tóth-Molnár E
Department of Ophthalmology, Albert Szent-Györgyi University, Szeged, Hungary.
Eur J Ophthalmol. 1996 Oct-Dec;6(4):472-4. doi: 10.1177/112067219600600423.
Many studies have characterized the phenotypic features of individuals who are likely to develop cutaneous melanoma. One of the major items included in melanoma risk assessment has been the presence of clinically atypical nevi (dysplastic nevi). This study assessed the number of subjects with dysplastic nevi in groups of patients with uveal melanoma or cutaneous melanoma and in a group of volunteer controls. The SPSS program was used to calculate the odds ratios (hereafter called relative risks; RR) and 95% confidence intervals (C) in melanoma patients and controls. The RR was 4.36 for uveal melanoma (95% Cl 1.84-10.36) and 4.22 for cutaneous melanoma (95% Cl 1.81-9.84). These results suggest that cutaneous dysplastic nevi are a significant risk factor for uveal melanoma.
许多研究已经描述了可能患皮肤黑色素瘤的个体的表型特征。黑色素瘤风险评估中的一个主要项目是临床上非典型痣（发育异常痣）的存在。本研究评估了葡萄膜黑色素瘤或皮肤黑色素瘤患者组以及一组志愿者对照组中患有发育异常痣的受试者数量。使用SPSS程序计算黑色素瘤患者和对照组的优势比（以下称为相对风险；RR）和95%置信区间（C）。葡萄膜黑色素瘤的RR为4.36（95%CI 1.84 - 10.36），皮肤黑色素瘤的RR为4.22（95%CI 1.81 - 9.84）。这些结果表明，皮肤发育异常痣是葡萄膜黑色素瘤的一个重要风险因素。
