Lerman J, Gregory G A, Eger E I
Anesth Analg. 1984 Oct;63(10):911-4.
To clarify the effect of hematocrit on the solubility of volatile anesthetics in blood, we measured the blood-gas partition coefficients of isoflurane, enflurane, halothane, and methoxyflurane concurrently at 37 degrees C in blood from four adults. We measured the blood-gas partition coefficients in the plasma (hematocrit 0%) and packed red cell fractions (hematocrit 80%), and in four mixtures of these two fractions (hematocrits 10%, 25%, 40%, and 55%). The mixtures were prepared by recombining appropriate amounts of plasma and packed red cells from each adult. As hematocrit increased, the blood-gas partition coefficient of isoflurane decreased linearly (P less than 0.01), whereas that of enflurane increased linearly (P less than 0.05). The partition coefficient for isoflurane in plasma was 20% greater than that in packed red cells, whereas the partition coefficient for enflurane in plasma was 10% less than that in packed cells. The blood-gas partition coefficients of halothane and methoxyflurane did not change significantly between measurements in plasma and packed red cells. We conclude that hematocrit exerts a statistically significant effect on the blood-gas partition coefficient of isoflurane and enflurane.
为阐明血细胞比容对挥发性麻醉剂在血液中溶解度的影响，我们在37℃下同时测量了来自四名成年人血液中异氟烷、恩氟烷、氟烷和甲氧氟烷的血气分配系数。我们测量了血浆（血细胞比容0%）和红细胞压积部分（血细胞比容80%）以及这两部分的四种混合物（血细胞比容10%、25%、40%和55%）中的血气分配系数。混合物通过重新组合来自每个成年人的适量血浆和红细胞压积来制备。随着血细胞比容的增加，异氟烷的血气分配系数呈线性下降（P<0.01），而恩氟烷的血气分配系数呈线性增加（P<0.05）。异氟烷在血浆中的分配系数比在红细胞压积中的高20%，而恩氟烷在血浆中的分配系数比在红细胞中的低10%。氟烷和甲氧氟烷在血浆和红细胞压积中的测量结果之间的血气分配系数没有显著变化。我们得出结论，血细胞比容对异氟烷和恩氟烷的血气分配系数有统计学上的显著影响。
