气相色谱法测定挥发性麻醉剂的溶解度系数（作者译）

[Gas chromatographic determination of the solubility coefficient for volatile anaesthetics (author's transl)].

作者信息

Lauven P M, Hack G, Stoeckel H

出版信息

Anaesthesist. 1979 Mar;28(3):104-6.

Abstract

For the determination of the solubility coefficient of volatile anaesthetics in Schindler's liquid culture, modified by Karzel, a gas-chromatographic analysis with direct-injection-method was used. A well defined volume with a known concentration of the anaesthetic was added to a vessel with known volume. After equilibration the concentration of the inhalational anaesthetics was determined in the liquid at various temperatures. The solubility coefficient and the temperature coefficient were then calculated from these data. We obtained the following solubility coefficients at -4 degrees C (37 degrees): for halothane 1,07 (0,77), for enflurane 1,14 (0,70), for methoxyflurane 4,92 (3,23) and for isoflurane 1,13 (0,82). In Schindler's liquid culture modified by Karzel the values at 24 degrees (37 degrees) were: for halothane 1,33 (0,92), for enflurane 1,32 (0,87), for methoxyflurane 6,61 (4,48) and for isoflurane 1,19 (0,98). The temperature coefficient for this temperature range were in water (in Schindler's liquid culture) for halothane: -2,31 . 10(-2) K(-1) (-3,15 . 10(-2) K(-1)), for methoxyflurane: -13,0 . 10(-2) K(-1) (-16,48 . 10(-2) K(-1)), for enflurane: -3,38 . 10(-2) K(-1) (-3,46 . 10(-2) K(-1)) and for isoflurane: -2,38 . 10(-2) K(-1) (-1,62 . 10(-2) K(-1)).

摘要

为测定经卡尔泽改良的辛德勒液体培养基中挥发性麻醉剂的溶解度系数，采用直接进样法进行气相色谱分析。将已知浓度的一定体积麻醉剂加入到已知体积的容器中。平衡后，在不同温度下测定液体中吸入麻醉剂的浓度。然后根据这些数据计算溶解度系数和温度系数。我们在-4℃（37℉）时得到以下溶解度系数：氟烷为1.07（0.77），恩氟烷为1.14（0.70），甲氧氟烷为4.92（3.23），异氟烷为1.13（0.82）。在经卡尔泽改良的辛德勒液体培养基中，24℃（37℉）时的值为：氟烷为1.33（0.92），恩氟烷为1.32（0.87），甲氧氟烷为6.61（4.48），异氟烷为1.19（0.98）。该温度范围内水（在辛德勒液体培养基中）中氟烷的温度系数为：-2.31×10⁻²K⁻¹（-3.15×10⁻²K⁻¹），甲氧氟烷为：-13.0×10⁻²K⁻¹（-16.48×10⁻²K⁻¹），恩氟烷为：-3.38×10⁻²K⁻¹（-3.46×10⁻²K⁻¹），异氟烷为：-2.38×10⁻²K⁻¹（-1.62×10⁻²K⁻¹）。