Meier D E, Orwoll E S, Jones J M
Ann Intern Med. 1984 Nov;101(5):605-12. doi: 10.7326/0003-4819-101-5-605.
To define age-related changes in bone mineral content in normal men, we measured radial (proximal and distal) and vertebral bone mineral content in 62 men aged 30 to 92 years. Radial bone mineral content (largely cortical bone) was measured by single photon absorptiometry, and trabecular vertebral content (T12, L1 to L3) by computed tomography. Radial bone mineral content fell gradually (2% to 3.4% per decade) with age, but vertebral trabecular content fell more rapidly (12% per decade). Body size was not associated with the rate of bone loss from the distal radial and vertebral sites, but men with lower surface areas lost bone more rapidly at the predominantly cortical proximal radial site. The fact that radial cortical bone mineral content falls much less rapidly than vertebral trabecular content with age and is also associated with surface area indicates that trabecular and cortical bone compartments may be independently modulated. Age-related bone loss should not be considered a homogeneous process.
为了确定正常男性骨矿物质含量与年龄相关的变化，我们测量了62名年龄在30至92岁男性的桡骨（近端和远端）及椎骨的骨矿物质含量。桡骨骨矿物质含量（主要为皮质骨）通过单光子吸收法测量，小梁椎骨含量（T12、L1至L3）通过计算机断层扫描测量。桡骨骨矿物质含量随年龄逐渐下降（每十年下降2%至3.4%），但椎骨小梁含量下降更快（每十年下降12%）。体型与桡骨远端和椎骨部位的骨质流失率无关，但表面积较小的男性在以皮质骨为主的桡骨近端部位骨质流失更快。随着年龄增长，桡骨皮质骨矿物质含量下降速度远低于椎骨小梁含量，且与表面积相关，这一事实表明小梁骨和皮质骨部分可能受到独立调节。与年龄相关的骨质流失不应被视为一个均匀的过程。
