Weinman E J, Senekjian H O, Knight T F
Nephron. 1979;23 Suppl 1:21-4. doi: 10.1159/000181663.
Clearance and micropuncture techniques were used to evaluate the effects of MK-196 on uric acid and electrolyte excretion by the rat kidney. The urinary excretion of sodium, uric acid, calcium and magnesium increased significantly following MK-196 administration. The major site of action with respect to sodium reabsorption was in the ascending limb of Henle's loop as revealed by depression of both free-water clearance and reabsorption. By contrast, microinjection studies with [2-14C]-urate revealed the major site of altered urate absorption to be in the proximal convoluted tubule, a site where sodium and water reabsorption was unchanged.
采用清除率和微穿刺技术评估MK-196对大鼠肾脏尿酸和电解质排泄的影响。给予MK-196后，钠、尿酸、钙和镁的尿排泄量显著增加。就钠重吸收而言，作用的主要部位是髓袢升支，这可通过自由水清除率和重吸收的降低来表明。相比之下，用[2-14C]尿酸进行的微注射研究表明，尿酸吸收改变的主要部位是近端曲管，而该部位的钠和水重吸收未发生变化。
