Kuznetsova S M, Samoĭlova L N, Speranskaia O N, Abadzhieva A N, Fomina I P
Antibiotiki. 1984 Aug;29(8):605-13.
The structure of the causative agents isolated from patients with pyoinflammatory infections in 1980-1983 was analysed. It was shown that the surgical and urological infections were mainly caused by gram-negative bacteria. The other pyoinflammatory infections were mainly due to gram-positive cocci. A relatively high frequency of the strains of gram-negative bacteria, especially among Pseudomonas spp. and Enterobacter spp., resistant to aminoglycoside antibiotics, such as gentamicin, sisomycin and tobramycin with preserved sensitivity to amikacin and netilmicin in the majority of the strains was shown. Among the beta-lactam antibiotics cephotaxim and cephalotin were most active against gram-negative bacteria and staphylococci, respectively. The majority of the antibiotic resistant strains of gram-negative bacteria had analogous structures and levels of resistance to 7-12 antibiotics which might indicate the occurrence of 1-2 resistance plasmids among the clinical strains.
对1980 - 1983年从脓性炎症感染患者中分离出的病原体结构进行了分析。结果表明，外科和泌尿系统感染主要由革兰氏阴性菌引起。其他脓性炎症感染主要由革兰氏阳性球菌引起。研究显示革兰氏阴性菌菌株，尤其是假单胞菌属和肠杆菌属中的菌株，对庆大霉素、西索米星和妥布霉素等氨基糖苷类抗生素具有较高频率的耐药性，而大多数菌株对阿米卡星和奈替米星仍保持敏感。在β - 内酰胺类抗生素中，头孢噻肟和头孢噻吩分别对革兰氏阴性菌和葡萄球菌最具活性。大多数革兰氏阴性菌的耐药菌株对7 - 12种抗生素具有类似的结构和耐药水平，这可能表明临床菌株中存在1 - 2种耐药质粒。
