Kirkham T C, Blundell J E
Appetite. 1984 Mar;5(1):45-52. doi: 10.1016/s0195-6663(84)80049-5.
In two experiments observational analyses have been made of eating and other behaviours following naloxone administration. Naloxone produced a clearly defined profile of behavioural changes. Although rats became became more inactive it was demonstrated that this was not responsible for the inhibition of food intake. The drug reduced the latency to approach food and to initiate eating bouts. In addition, naloxone hastened the termination of eating in the test period. Therefore naloxone simultaneously increases one aspect of motivation for food, yet also promotes the onset of satiation. This profile of naloxone's anorexic action is quite different to that of traditional anorexic drugs such as amphetamine of fenfluramine. This dual action of naloxone, disclosed by these studies, may account for certain curious features of naloxone's effect on food intake.
在两项实验中，对注射纳洛酮后的进食及其他行为进行了观察分析。纳洛酮产生了明确的行为变化特征。尽管大鼠变得更加不活跃，但已证明这并非抑制食物摄入的原因。该药物缩短了接近食物和开始进食的潜伏期。此外，纳洛酮加速了测试期间进食的终止。因此，纳洛酮同时增加了对食物的一种动机，但也促进了饱腹感的产生。纳洛酮这种厌食作用的特征与传统厌食药物如苯丙胺或芬氟拉明的特征截然不同。这些研究揭示的纳洛酮的这种双重作用，可能解释了纳洛酮对食物摄入影响的某些奇特特征。
