Kirkham T C, Blundell J E
Pharmacol Biochem Behav. 1987 Mar;26(3):515-20. doi: 10.1016/0091-3057(87)90158-4.
The effects of naloxone and naltrexone on the night-time meal patterning of freely-feeding male rats were investigated using a Kissileff-type eatometer. Naloxone (5.0 mg/kg) and naltrexone (2.5 mg/kg) reduced intake for two hours after IP injection. This effect resulted from a shortening of duration of meals and an extension of postmeal intervals. Unlike other anorexic agents neither drug affected meal frequency or the eating rate within meals. These particular opioid antagonists therefore appear to produce anorexia by advancing meal termination and extending the inhibition of feeding which follows a meal. These specific changes in the structure of the meal pattern consolidate previous findings and support the hypothesis that naloxone and naltrexone reduce food intake in rats by promoting satiation and prolonging satiety.
使用基西列夫型进食量测定仪研究了纳洛酮和纳曲酮对自由进食雄性大鼠夜间进食模式的影响。腹腔注射后，纳洛酮（5.0毫克/千克）和纳曲酮（2.5毫克/千克）使大鼠在两小时内摄入量减少。这种效应是由于进食持续时间缩短和餐后间隔延长所致。与其他厌食剂不同，这两种药物均不影响进食频率或进食期间的进食速度。因此，这些特定的阿片类拮抗剂似乎通过提前终止进食和延长餐后对进食的抑制来产生厌食作用。进食模式结构的这些特定变化巩固了先前的研究结果，并支持了纳洛酮和纳曲酮通过促进饱腹感和延长饱腹感来减少大鼠食物摄入量的假说。
