Tatsumi K, Nakabeppu H, Takahashi Y, Kitamura S
Arch Biochem Biophys. 1984 Oct;234(1):112-6. doi: 10.1016/0003-9861(84)90330-8.
The in vivo metabolism of an antibacterial nitrofuran, furazolidone [N-(5-nitro-2-furfurylidene)-3-amino-2-oxazolidone] was investigated. When the nitrofuran was administered orally to rats, two new-type nitrofuran metabolites, N-(4-carboxy-2-oxobutylideneamino)-2-oxazolidone and alpha-ketoglutaric acid, were isolated from the urine, together with 3-(4-cyano-2-oxobutylideneamino)-2-oxazolidone and N-(5-acetamido-2-furfurylidene)-3-amino-2-oxazolidone. In addition, the present study showed that the corresponding aminofuran was an intermediate in the conversion of furazolidone to these metabolites.
研究了一种抗菌硝基呋喃——呋喃唑酮[N-(5-硝基-2-糠叉基)-3-氨基-2-恶唑烷酮]的体内代谢情况。当向大鼠口服该硝基呋喃时，从尿液中分离出两种新型硝基呋喃代谢产物，即N-(4-羧基-2-氧代丁叉基氨基)-2-恶唑烷酮和α-酮戊二酸，同时还分离出3-(4-氰基-2-氧代丁叉基氨基)-2-恶唑烷酮和N-(5-乙酰氨基-2-糠叉基)-3-氨基-2-恶唑烷酮。此外，本研究表明相应的氨基呋喃是呋喃唑酮转化为这些代谢产物过程中的中间体。
