Samuelsen O B, Solheim E, Lunestad B T
Department of Pharmacology and Toxicology, School of Medicine, University of Bergen, Norway.
Sci Total Environ. 1991 Oct 15;108(3):275-83. doi: 10.1016/0048-9697(91)90364-k.
Furazolidone is used in the treatment of bacterial diseases in farmed fish. During application a large proportion of the administered drug reaches the environment directly or via feces. The persistence and metabolism of furazolidone in sediment from a Norwegian salmon farm is described. Furazolidone, in contrast to oxytetracycline and oxolinic acid, is actively metabolized by microorganisms in the sediment. The main metabolite is 3-(4-cyano-2-oxobutylidene-amino)-2-oxazolidone. This is a well known metabolite of the degradation of furazolidone in mammals, fish and Escherichia coli. 3-(4-Cyano-2-oxobutylideneamino)-2- oxazolidone had no detectable antibacterial activity. The half-life of furazolidone in the sediment at 4 degrees C was calculated to be 18 h.
呋喃唑酮用于治疗养殖鱼类的细菌性疾病。在使用过程中，很大一部分施用的药物直接或通过粪便进入环境。本文描述了呋喃唑酮在挪威鲑鱼养殖场沉积物中的持久性和代谢情况。与土霉素和恶喹酸不同，呋喃唑酮在沉积物中会被微生物积极代谢。主要代谢产物是3-(4-氰基-2-氧代丁烯基)-氨基-2-恶唑烷酮。这是呋喃唑酮在哺乳动物、鱼类和大肠杆菌中降解的一种众所周知的代谢产物。3-(4-氰基-2-氧代丁烯基)-氨基-2-恶唑烷酮没有可检测到的抗菌活性。在4摄氏度下，呋喃唑酮在沉积物中的半衰期经计算为18小时。
