Verity C M, Vanheule B, Carswell F, Hughes A O
Arch Dis Child. 1984 Sep;59(9):871-6. doi: 10.1136/adc.59.9.871.
Seventy five children with asthma (42 boys and 33 girls; age range 4 years 2 months to 15 years) and 75 of their siblings (37 boys and 38 girls; age range 4 years 3 months to 17 years 8 months) were studied to elucidate the mechanisms involved in the increased prevalence of asthma in boys, a prevalence that tends to disappear after puberty. Immediate cutaneous hypersensitivity to five allergens and maximum fall in peak expiratory flow rate after six minutes of treadmill running (bronchial lability) were determined in patients and siblings. There was no significant difference between boys and girls in skin test reactivity to single or multiple allergens in the sibling group. The percentage fall in peak expiratory flow rate after exercise was significantly greater in male than in female siblings and when a positive test was defined as a fall after exercise of either 10% or 15% of the rate before exercise the number of positive tests was significantly greater in boys. The results suggest that more boys than girls in this age group have asthma because their bronchial lability is greater, and not because more boys are atopic.
对75名哮喘患儿（42名男孩和33名女孩；年龄范围为4岁2个月至15岁）及其75名兄弟姐妹（37名男孩和38名女孩；年龄范围为4岁3个月至17岁8个月）进行了研究，以阐明男孩哮喘患病率增加的机制，这种患病率在青春期后往往会消失。测定了患者及其兄弟姐妹对五种过敏原的即刻皮肤超敏反应以及在跑步机上跑步六分钟后的最大呼气流量下降（支气管易激性）。在兄弟姐妹组中，男孩和女孩对单一或多种过敏原的皮肤试验反应性没有显著差异。运动后呼气峰值流速下降的百分比在男性兄弟姐妹中显著高于女性，并且当将运动后下降10%或15%的测试定义为阳性测试时，男孩的阳性测试数量显著更多。结果表明，该年龄组中患哮喘的男孩比女孩多，是因为他们的支气管易激性更大，而不是因为更多男孩具有特应性。
