Houbouyan L, Armengaud D, Leroy B, Roussi J, Gallet J P, Goguel A
Arch Fr Pediatr. 1984 Jun-Jul;41(6):417-20.
A 2 year-old female developed an acute bleeding diathesis related to a profound, isolated and acquired prothrombin deficiency; evidence for a "lupus anticoagulant" was also demonstrated. This association of hypoprothrombinemia and "lupus anticoagulant", rarely reported, was previously considered to be rather specific for SLE. This case report demonstrates that these coagulation disorders may present as an acute form, in viral diseases of the child, with spontaneous and quick recovery. Specific characteristics of the biological coagulation defects, namely those related to the low factor II, are discussed.
一名2岁女性出现急性出血素质，与严重、孤立且后天获得的凝血酶原缺乏有关；同时也证实了“狼疮抗凝物”的存在。凝血酶原血症减低与“狼疮抗凝物”的这种关联很少有报道，以前被认为是系统性红斑狼疮（SLE）相当特异的表现。本病例报告表明，这些凝血障碍在儿童病毒性疾病中可能以急性形式出现，并能自发且快速恢复。文中讨论了生物凝血缺陷的具体特征，即与低凝血因子II相关的特征。
