Mauduit G, Souteyrand P, Thivolet J
Ann Dermatol Venereol. 1982;109(6-7):557-64.
We report the observations of 4 young women suffering from SLE witha circulatig antiprothrombinase anticoagulant. Antiprothrombinase is the most frequent circulating anticoagulant found in SLE (5 to 10 p. 100). SLE is the main aetiology for antiprothrombinase (over 50 p. 100). It is called 'lupus anticoagulant'. Some symptoms seem to be more frequent in SLE with antiprothrombinase. Such are biological signs (false positive tests for syphilis. Coombs test, thrombopenia, prothrombin deficiency) and clinical signs (venous or arterial thrombosis particularly if oestroprogestative treatment is taken, bleeding if thrombocytopenia or deficiency of prothrombin; repetitive abortion and may be neuropsychiatric signs). Antiprothrombinase is an autoantibody (IgG or IgG + M) polyclonal in SLE, with antiphospholipid activity. It could decrease the production of prostacyclin (PGI2) from free arachidonic acid derived from membrane bound phospholipids. Immunological properties of antiprothrombinase could account for clinical and biological associated signs.
我们报告了4例患有系统性红斑狼疮（SLE）且伴有循环抗凝血酶原酶抗凝物质的年轻女性的观察结果。抗凝血酶原酶是在SLE中最常见的循环抗凝物质（每100例中有5至10例）。SLE是抗凝血酶原酶的主要病因（超过每100例中的50例）。它被称为“狼疮抗凝物质”。在伴有抗凝血酶原酶的SLE中，某些症状似乎更为常见。这些症状包括生物学指标（梅毒假阳性试验、库姆斯试验、血小板减少、凝血酶原缺乏）和临床体征（静脉或动脉血栓形成，特别是在接受雌激素 - 孕激素治疗时；血小板减少或凝血酶原缺乏时出血；反复流产，可能还有神经精神症状）。抗凝血酶原酶是SLE中的一种自身抗体（IgG或IgG + M），多克隆性，具有抗磷脂活性。它可能会减少由膜结合磷脂衍生的游离花生四烯酸生成前列环素（PGI2）。抗凝血酶原酶的免疫学特性可以解释相关的临床和生物学体征。
