Nishioka H, Torner J C, Graf C J, Kassell N F, Sahs A L, Goettler L C
Arch Neurol. 1984 Nov;41(11):1147-51. doi: 10.1001/archneur.1984.04050220041012.
Among 6,638 cases reported to the Cooperative Study of Intracranial Aneurysms and Subarachnoid Hemorrhage were 477 cases in which the cause of hemorrhage could not be determined after carotid and vertebral angiography. These patients were followed up for up to 24 years after hemorrhage. Twenty patients were subsequently found to have an aneurysm or arteriovenous malformation missed by the first angiographic survey. After six-month survival, the rate of recurrent hemorrhage was a maximum 0.86% per year. Survival was significantly better than that of patients with verified ruptured aneurysms managed conservatively in this cooperative study. For normotensive patients who survived the first six months, the life expectancy for the next 20 years equaled that of an age- and sex-matched US population. Hypertensive patients had a higher mortality than normotensive patients.
在向颅内动脉瘤与蛛网膜下腔出血合作研究项目报告的6638例病例中，有477例在进行颈动脉和椎动脉血管造影后仍无法确定出血原因。这些患者在出血后接受了长达24年的随访。随后发现，有20例患者存在首次血管造影检查遗漏的动脉瘤或动静脉畸形。在存活6个月后，复发性出血率最高为每年0.86%。在该合作研究中，其存活率显著高于经保守治疗的已证实破裂动脉瘤患者。对于在前6个月存活下来的血压正常患者，接下来20年的预期寿命与年龄和性别匹配的美国人群相当。高血压患者的死亡率高于血压正常的患者。
