正常和病理性人玻璃体的血管内皮细胞生长抑制剂

Vascular endothelial cell growth inhibitor of normal and pathologic human vitreous.

作者信息

Jacobson B, Basu P K, Hasany S M

出版信息

Arch Ophthalmol. 1984 Oct;102(10):1543-5. doi: 10.1001/archopht.1984.01040031259031.

DOI:10.1001/archopht.1984.01040031259031

Abstract

Normal and pathologic human vitreous have been analyzed for the presence of a low-molecular weight inhibitor of aortic endothelial cell proliferation. Vitreous was subjected to gel chromatography and the material appearing in the retarded volume (less than 13,000 daltons) was tested for its ability to inhibit tritiated thymidine incorporation into DNA by calf aortic endothelial cells. Depending on the sample of vitreous analyzed, one or more fractions showing inhibitory activity were identified in each case.

摘要

已对正常和病理状态的人体玻璃体进行分析，以检测是否存在一种抑制主动脉内皮细胞增殖的低分子量抑制剂。将玻璃体进行凝胶色谱分析，对出现在滞留体积（小于13,000道尔顿）中的物质检测其抑制氚标记胸腺嘧啶核苷掺入小牛主动脉内皮细胞DNA的能力。根据所分析的玻璃体样本，每种情况下均鉴定出一种或多种具有抑制活性的组分。