Concomitant administration of timolol and hydrochlorothiazide/amiloride in hypertensive patients. Results of a titration study.

In an open dose titration study we evaluated the antihypertensive effect of the concomitant administration of timolol and hydrochlorothiazide/amiloride, administered on a b.i.d. basis. Twenty-eight out of 39 patients completed the study. Supine and standing systolic and diastolic blood pressures and pulse rate were significantly lower at the end of the titration period than at the end of the diuretic period.