Prokazova N V, Kocharov S L, Isaev I V, Fomina-Ageeva E V, Shaposhnikova G I
Bioorg Khim. 1984 Feb;10(2):238-43.
The structure of the neutral glycosphingolipids of the Ehrlich ascite carcinoma (EAC) cells was studied. The main four components were identified as glycosylceramide, lastosylceramide, N-acetylgalactosyllactosylceramide and galactosyl-N-acetyllactosylceramide (asialo-GM1). The neutral glycolipid pattern of the cells was found to depend on their density. Dilution of the cell suspension resulted in an increased content of asia-lo-GM1, whereas the content of the other neutral glycolipids remained unchanged. The possible connection between these changes and the earlier disclosed cell density dependence of the gangliosides in EAC cells is discussed.
对艾氏腹水癌细胞中性糖鞘脂的结构进行了研究。确定了主要的四种成分分别为糖基神经酰胺、乳糖基神经酰胺、N-乙酰半乳糖基乳糖基神经酰胺和半乳糖基-N-乙酰乳糖基神经酰胺（脱唾液酸GM1）。发现细胞的中性糖脂模式取决于其密度。细胞悬液的稀释导致脱唾液酸GM1含量增加，而其他中性糖脂的含量保持不变。讨论了这些变化与早期揭示的艾氏腹水癌细胞中神经节苷脂对细胞密度的依赖性之间的可能联系。
