噻嗪类药物所致低钾血症；女性患病率更高。
Thiazide-induced hypokalaemia; prevalence higher in women.
作者信息
Toner J M, Ramsay L E
出版信息
Br J Clin Pharmacol. 1984 Sep;18(3):449-52. doi: 10.1111/j.1365-2125.1984.tb02488.x.
Abstract
In 193 hypertensive patients taking bendrofluazide 5 mg daily, the mean serum potassium concentration was lower in women than in men (3.77 vs 3.99 mmol/l, P less than 0.001) and the prevalence of hypokalaemia (less than 3.5 mmol/l) was higher (25% vs 12%, P less than 0.05). This difference between the sexes was independent of age, body weight, renal function, the use of other antihypertensive drugs and compliance with treatment as judged by tablet counts. Severe hypokalaemia (less than 3.0 mmol/l) was uncommon and showed no difference between the sexes.
摘要
在193例每日服用5毫克苄氟噻嗪的高血压患者中，女性的平均血清钾浓度低于男性（3.77 vs 3.99毫摩尔/升，P<0.001），低钾血症（低于3.5毫摩尔/升）的患病率更高（25% vs 12%，P<0.05）。根据片剂计数判断，这种性别差异与年龄、体重、肾功能、其他降压药物的使用以及治疗依从性无关。严重低钾血症（低于3.0毫摩尔/升）并不常见，且在性别上无差异。
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