Laursen L C, Johannesson N, Søndergaard I, Weeke B
Br J Clin Pharmacol. 1984 Oct;18(4):591-5. doi: 10.1111/j.1365-2125.1984.tb02509.x.
Bronchodilating effects produced by increasing intravenously administered doses of enprofylline and theophylline compared to placebo were evaluated in 20 asthmatic outpatients. Three mean plasma plateaux of enprofylline of 1.5, 2.9 and 4.0 micrograms/ml produced a mean increase in forced expiratory volume in the first second (FEV1.0) as a percentage of baseline, of 12.8%, 18.8% and 30.1%, respectively. Comparable plasma plateaux of theophylline i.e. 5.5, 10.8 and 15.2 micrograms/ml produced a mean increase of FEV1.0 in percent of basal values of 12.4%, 21.6% and 28.2%, respectively. Enprofylline at plasma concentrations above 2.9 micrograms/ml induced more headache and slightly more nausea than theophylline and placebo. Theophylline infusion produced more tremor (finger oscillation) than enprofylline and placebo. Intravenously administered enprofylline produces bronchodilation comparable to theophylline in a mean dose ratio of 3.8.
在20名哮喘门诊患者中评估了与安慰剂相比，静脉注射递增剂量的恩丙茶碱和茶碱所产生的支气管扩张作用。恩丙茶碱的三个平均血浆平稳浓度分别为1.5、2.9和4.0微克/毫升，第一秒用力呼气量（FEV1.0）相对于基线的平均增加百分比分别为12.8%、18.8%和30.1%。茶碱的可比血浆平稳浓度，即5.5、10.8和15.2微克/毫升，FEV1.0相对于基础值的平均增加百分比分别为12.4%、21.6%和28.2%。血浆浓度高于2.9微克/毫升的恩丙茶碱比茶碱和安慰剂诱发更多的头痛和稍多的恶心。茶碱输注比恩丙茶碱和安慰剂产生更多的震颤（手指摆动）。静脉注射恩丙茶碱产生的支气管扩张作用与茶碱相当，平均剂量比为3.8。
