茶碱对甲状腺毒症性震颤的影响。
The effect of theophylline on thyrotoxic tremor.
作者信息
Buss D C, Phillips D I, Littley M D, Marshall R W, Routledge P A, Lazarus J H
机构信息
Department of Clinical Pharmacology, University of Wales College of Medicine, Llandough Hospital, Penarth, South Glamorgan.
出版信息
Br J Clin Pharmacol. 1989 Jul;28(1):103-7. doi: 10.1111/j.1365-2125.1989.tb03511.x.
Abstract
- The effect of intravenous aminophylline on theophylline-induced tremor were studied in six hyperthyroid patients before and after treatment to euthyroidism. 2. Baseline tremor power was significantly greater in the hyperthyroid compared with the euthyroid state (P less than 0.05). 3. Aminophylline produced a significantly greater increase in tremor power in the hyperthyroid compared with euthyroid state. 4. There was a significant increase in plasma theophylline clearance and reduction in t1/2 elimination when patients were hyperthyroid but volume of distribution did not change. 5. Intravenous aminophylline potentiates the tremor produced in hyperthyroidism despite an increase in plasma theophylline clearance. A pharmacodynamic mechanism is therefore likely.
摘要
- 研究了6例甲状腺功能亢进患者在治疗至甲状腺功能正常前后，静脉注射氨茶碱对茶碱诱发震颤的影响。2. 与甲状腺功能正常状态相比，甲状腺功能亢进时的基线震颤功率显著更高（P小于0.05）。3. 与甲状腺功能正常状态相比，氨茶碱在甲状腺功能亢进时使震颤功率增加得更为显著。4. 患者处于甲状腺功能亢进状态时，血浆茶碱清除率显著增加，t1/2消除时间缩短，但分布容积未改变。5. 尽管血浆茶碱清除率增加，但静脉注射氨茶碱仍会增强甲状腺功能亢进时产生的震颤。因此，可能存在一种药效学机制。
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