云母尘与胆碱对大鼠淋巴结的影响。

Sahu A P, Shukla L J, Murti C R

Br J Exp Pathol. 1984 Oct;65(5):533-41.

Male albino rats given choline alone by intraperitoneal injection (40 doses of 25 mg/5 days a week over a period of 10 weeks), developed atypical lymphadenopathy at the end of the experiment (330 days). In a second group, the intratracheal instillation of single dose of 25 mg of respirable mica provoked proliferation of reticular cells and macrophages in the tracheobronchial lymph nodes. However, in a third group, the combined action of choline and mica caused marked lymphadenopathy with abnormal cells. The role of choline, an essential component of cell membrane, in enhancing the reaction to mica in the lymph nodes, is discussed.

通过腹腔注射单独给予胆碱的雄性白化病大鼠（每周5天，共40剂，每剂25毫克，持续10周），在实验结束时（330天）出现了非典型淋巴结病。在第二组中，气管内单次滴注25毫克可吸入云母会引起气管支气管淋巴结中网状细胞和巨噬细胞的增殖。然而，在第三组中，胆碱和云母的联合作用导致了伴有异常细胞的明显淋巴结病。本文讨论了细胞膜的重要组成部分胆碱在增强淋巴结对云母反应中的作用。