Iacopetta B, Morgan E
Biochim Biophys Acta. 1984 Oct 12;805(2):211-6. doi: 10.1016/0167-4889(84)90170-8.
The inhibitory effect of heme on iron uptake from transferrin by rat and rabbit reticulocytes and erythroid cells from the fetal rat liver was studied in vitro. Addition of hemin was shown to cause a decrease in the rate of transferrin endocytosis, the degree of inhibition being proportional to the reduction in iron uptake. The heme synthesis inhibitors, isoniazid and succinylacetone, stimulated the rate of transferrin endocytosis by 15-30% and caused a proportional increase in the rate of iron uptake, possibly by reducing the intracellular free heme concentration. It is concluded from these results that heme affects iron uptake by influencing the rate of transferrin endocytosis and recycling.
在体外研究了血红素对大鼠、家兔网织红细胞以及胎鼠肝脏红系细胞从转铁蛋白摄取铁的抑制作用。结果表明，加入血红素会导致转铁蛋白内吞速率降低，抑制程度与铁摄取的减少成比例。血红素合成抑制剂异烟肼和琥珀酰丙酮使转铁蛋白内吞速率提高了15% - 30%，并使铁摄取速率成比例增加，这可能是通过降低细胞内游离血红素浓度实现的。从这些结果得出结论，血红素通过影响转铁蛋白内吞和再循环速率来影响铁摄取。
