血红素抑制网织红细胞中转铁蛋白内吞作用后铁的摄取。
Haem inhibits iron uptake subsequent to endocytosis of transferrin in reticulocytes.
作者信息
Ponka P, Schulman H M, Martinez-Medellin J
机构信息
Department of Physiology, McGill University, Montreal, Quebec, Canada.
出版信息
Biochem J. 1988 Apr 1;251(1):105-9. doi: 10.1042/bj2510105.
Abstract
Haem controls the rate of haem synthesis in erythroid cells by inhibiting iron incorporation from transferrin. The present results indicate that haem primarily inhibits the release of iron from transferrin subsequent to transferrin endocytosis and that the inhibition of transferrin endocytosis caused by relatively high concentrations of haem is a secondary effect. Low concentrations of haem (10-25 microM) significantly inhibit reticulocyte iron uptake and to a greater extent its incorporation into haem, but do not inhibit either the initial rate of transferrin uptake or its internalization by the cells.
摘要
血红素通过抑制转铁蛋白中的铁掺入来控制红系细胞中血红素的合成速率。目前的结果表明，血红素主要抑制转铁蛋白内吞后铁从转铁蛋白的释放，而相对高浓度的血红素所引起的转铁蛋白内吞抑制是一种次要效应。低浓度的血红素（10 - 25微摩尔）显著抑制网织红细胞对铁的摄取，并且在更大程度上抑制其掺入血红素中，但既不抑制转铁蛋白摄取的初始速率，也不抑制细胞对其的内化作用。
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