Lanir Y
Biorheology. 1984;21(4):643-7. doi: 10.3233/bir-1984-21421.
The possibility of fluid flux within the thickened subendothelial intima is considered. Both the media and the endothelium were already shown to be major hydraulic barriers. It is hypothesized that if the hydraulic conductivity of the inbetween layer of the subendothelial intima is considerably higher, then fluid flux in the downstream (axial) direction is likely to occur within the intima as a result of the luminal blood pressure wave. Macromolecular species (as lipoproteins) would then be transported axially by the fluid. This convective transport may give rise to the formation of early atheromas. The proposed mechanism is in accord with several clinical and experimental observations.
考虑了增厚的内皮下内膜内液体通量的可能性。中膜和内皮都已被证明是主要的水力屏障。据推测，如果内皮下内膜中间层的水力传导率显著更高，那么由于管腔内血压波的作用，内膜内可能会出现沿下游（轴向）方向的液体通量。大分子物质（如脂蛋白）随后将被液体轴向运输。这种对流运输可能导致早期动脉粥样硬化斑块的形成。所提出的机制与一些临床和实验观察结果一致。
