Hendry J H
Br J Radiol. 1984 Oct;57(682):909-18. doi: 10.1259/0007-1285-57-682-909.
The sensitivity of epidermal colony-forming units (CFU) in the mouse tail has been compared with the sensitivity of target units responsible for healing the epidermis (EHU). The value of D0 for epidermal CFU was 3.45 +/- 0.36 Gy, much higher than most earlier reports for CFU in dorsal epidermis. The reason for the high D0 is unknown, but it is considered unlikely to be due to marked hypoxia. The value of D0 for EHU was 2.78 +/- 0.51 Gy, which was deduced from the steepness of the dose-incidence curve for the healing of tails. A comparison of the two values of D0 indicates that the inactivation rate of CFU can account for the steepness of the dose-response curve for survival of the tissue. The dose which allowed 50% of tails to heal well corresponded to 3-4 colonies per cm2 of epidermis, to a median peak skin reaction of about 2 (moist desquamation) on an arbitrary scoring scale, and to a slightly lower median skin reaction of 1.7 when the reaction scores were averaged over the period 3 to 6 weeks after irradiation.
已对小鼠尾巴表皮集落形成单位（CFU）的敏感性与负责表皮愈合的靶单位（EHU）的敏感性进行了比较。表皮CFU的D0值为3.45±0.36 Gy，远高于大多数早期关于背部表皮CFU的报道。D0值较高的原因尚不清楚，但认为不太可能是由于明显的缺氧。EHU的D0值为2.78±0.51 Gy，这是根据尾巴愈合的剂量-发生率曲线的斜率推导出来的。对两个D0值的比较表明，CFU的失活率可以解释组织存活剂量-反应曲线的斜率。使50%的尾巴愈合良好的剂量相当于每平方厘米表皮有3 - 4个集落，在任意评分量表上对应的皮肤反应中位数峰值约为2（湿性脱皮），而在照射后3至6周期间平均反应评分时，皮肤反应中位数略低，为1.7。
