Pearce B R, Bowen D M
Brain Res. 1984 Sep 24;310(2):376-8. doi: 10.1016/0006-8993(84)90164-1.
The binding of [3H]kainic acid to caudate nucleus membranes prepared from brains of examples of Alzheimer's dementia and controls has been determined. No changes were detected in either the affinity or the number of kainate binding sites in the Alzheimer samples compared to control, although there was a large decrease in choline acetyltransferase activity.
已测定了[3H] kainic酸与从阿尔茨海默病痴呆症患者及对照者大脑制备的尾状核膜的结合情况。与对照组相比，阿尔茨海默病样本中kainate结合位点的亲和力或数量均未检测到变化，尽管胆碱乙酰转移酶活性大幅下降。
