Henke H
Neurosci Lett. 1979 Oct;14(2-3):247-51. doi: 10.1016/0304-3940(79)96156-1.
Kainic acid binding was measured in crude membrane fractions prepared from postmortem human caudate tissue of control persons and patients afflicted with Huntington's disease. A significant reduction in binding sites with no change in affinity was found in the Huntington's tissue, the apparent dissociation constants (Kd) and maximal binding (Bmax) values were: 6.4 nM/119 fmol/mg protein (control) and 5.9 nM/53 fmol/mg protein (Huntington). The kainic acid binding showed a remarkable specificity for L-glutamate.
在从对照者和患有亨廷顿病患者的死后人类尾状核组织制备的粗膜级分中测量了海人酸结合。在亨廷顿病组织中发现结合位点显著减少而亲和力无变化，表观解离常数（Kd）和最大结合（Bmax）值分别为：6.4 nM/119 fmol/mg蛋白质（对照）和5.9 nM/53 fmol/mg蛋白质（亨廷顿病）。海人酸结合对L-谷氨酸表现出显著的特异性。
