Collier T J, Routtenberg A
Brain Res. 1984 Sep 24;310(2):384-7. doi: 10.1016/0006-8993(84)90166-5.
Albino rats received 10 s of sub-seizure electrical stimulation applied to the dentate gyrus granule cells immediately after acquisition of information on trial 1 of a 2-trial radial maze spatial memory task. Granule cell stimulation selectively reduced the probability of accessing information held in declarative memory ('knowing that' a particular maze location contains food) while leaving procedural memory intact ('knowing how' to search for food in the maze). This specific memory impairment was prevented by pretreatment with the opiate antagonist naloxone. Naloxone also improved memory performance when given to non-stimulated subjects.
在一项双试次放射状迷宫空间记忆任务的第1次试次获取信息后，立即对白化大鼠的齿状回颗粒细胞施加10秒的亚癫痫电刺激。颗粒细胞刺激选择性地降低了获取陈述性记忆中信息的概率（“知道”特定迷宫位置有食物），同时保持程序性记忆完好无损（“知道如何”在迷宫中寻找食物）。阿片拮抗剂纳洛酮预处理可预防这种特定的记忆损伤。给予未受刺激的受试者纳洛酮时，其记忆表现也得到改善。
