Bostock E, Gallagher M, King R A
Psychology Department, University of North Carolina-Chapel Hill.
Behav Neurosci. 1988 Oct;102(5):643-52. doi: 10.1037//0735-7044.102.5.643.
Recent work has demonstrated that posttraining systemic opioid antagonist administration facilitates the acquisition of a radial arm maze task in new spatial environments. In this study, we examined the effect of posttraining naloxone and beta-endorphin microinjections into the medial septal area on the acquisition of a radial maze task in new spatial environments. The results of these experiments demonstrated that posttraining intraseptal naloxone administration facilitated, whereas posttraining intraseptal beta-endorphin administration impaired, the acquisition of criterion performance on a maze task performed in new spatial environments. Further, intraventricular beta-endorphin administration did not produce effects that were comparable to those observed following intraseptal beta-endorphin administration, which indicates that the septal region is a brain site that is sensitive to the effects of opioids on spatial memory in new environments. Further, posttraining intraseptal beta-endorphin administration had no effect on working memory in a familiar spatial environment, whereas pretraining intraseptal beta-endorphin administration had no effect on the performance of a previously acquired spatial task.
最近的研究表明，训练后给予全身性阿片类拮抗剂有助于在新的空间环境中习得放射状臂迷宫任务。在本研究中，我们检测了训练后向内侧隔区微量注射纳洛酮和β-内啡肽对在新空间环境中习得放射状迷宫任务的影响。这些实验结果表明，训练后向隔区内注射纳洛酮有助于任务习得，而训练后向隔区内注射β-内啡肽则损害了在新空间环境中进行迷宫任务时标准行为的习得。此外，脑室内注射β-内啡肽并未产生与隔区内注射β-内啡肽后观察到的效果相当的影响，这表明隔区是对阿片类药物在新环境中对空间记忆的影响敏感的脑区。此外，训练后向隔区内注射β-内啡肽对熟悉空间环境中的工作记忆没有影响，而训练前向隔区内注射β-内啡肽对先前习得的空间任务的表现没有影响。
