Fanelli R J, Rosenberg R A, Gallagher M
Behav Neurosci. 1985 Aug;99(4):751-5. doi: 10.1037//0735-7044.99.4.751.
Animals previously trained to criterion on an eight-arm radial maze task received either bilateral 6-hydroxydopamine lesions of the dorsal noradrenergic bundle (DNB) or control surgery. Following a 3-week recovery period, the animals were trained on the same radial maze in two novel environments. By a within-subjects design, in one of these environments animals received posttraining systemic treatment with the opiate antagonist naloxone; in the other novel environment, they received vehicle injection. In animals that received control surgery, opiate antagonist treatment produced a reliable enhancement of performance. Although the DNB-lesion animals did not differ from the control-surgery animals under the saline treatment condition, denervation of forebrain norepinephrine (NE) was found to prevent the memory enhancing effect of posttraining naloxone administration. These results provide further support that enhanced retention obtained with opiate antagonist administration is dependent upon intact NE function.
先前在八臂放射状迷宫任务中训练至标准的动物接受了双侧背去甲肾上腺素能束（DNB）的6-羟基多巴胺损伤或对照手术。经过3周的恢复期后，这些动物在两个新环境中在相同的放射状迷宫上进行训练。采用被试内设计，在其中一个环境中，动物在训练后接受阿片拮抗剂纳洛酮的全身治疗；在另一个新环境中，它们接受载体注射。在接受对照手术的动物中，阿片拮抗剂治疗产生了可靠的行为表现增强。尽管在生理盐水治疗条件下，DNB损伤动物与对照手术动物没有差异，但发现前脑去甲肾上腺素（NE）去神经支配可阻止训练后给予纳洛酮的记忆增强作用。这些结果进一步支持了阿片拮抗剂给药所获得的增强记忆依赖于完整的NE功能。
