1-硫代-胞壁酰-L-丙氨酰-D-异谷氨酰胺的一些亲脂性衍生物的合成与生物活性
Synthesis and biological activity of some lipophilic derivatives of 1-thio-muramoyl-L-alanyl-D-isoglutamine.
作者信息
Hasegawa A, Seki E, Hioki Y, Kiso M, Azuma I
出版信息
Carbohydr Res. 1984 Aug 1;131(1):61-9. doi: 10.1016/0008-6215(84)85404-x.
PMID:6488202
Abstract
2-N-Octadecanoyl derivatives of 1-S-acetyl-, 1-S-octadecanoyl-, and of 6-O-octadecanoyl-1-S-octadecanoyl-1-thiomuramoyl-L-ala nyl-D-isoglutamine were synthesized from benzyl 3,4,6-tri-O-acetyl-2-deoxy-2-(octadecanoylamino)-beta-D-glucopy ran oside. Their immunoadjuvant activities were examined in guinea-pigs.
摘要
由苄基3,4,6-三-O-乙酰基-2-脱氧-2-(十八烷酰氨基)-β-D-吡喃葡萄糖苷合成了1-S-乙酰基-、1-S-十八烷酰基-以及6-O-十八烷酰基-1-S-十八烷酰基-1-硫代Muramoyl-L-丙氨酰-D-异谷氨酰胺的2-N-十八烷酰衍生物。在豚鼠中检测了它们的免疫佐剂活性。
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